RESEARCH ARTICLE Chronic Hepatitis B Virus Infection and Riskwould like to thank ethiopian red cross society of blood bank organization, for helping us in serological screening of hbv. department of obstetrics & gynecology, university of texas southwestern medical center. b virus (hbv) infection is the most common and serious liver infection in the world. in every district, 9 subdivisions were chosen randomly using proportional population size (pps). the prevalence of hepatitis b virus surface antigen (hbsag) in hyper-endemic, endemic and hypo-endemic areas is more than 8%, 2% to 7% and less than 2%, respectively (3, 7). hbeab had its lowest frequency of 20 percent among individuals older than 60. this finding may be explained as since hepatitis b is blood born virus; blood, semen and other body fluids are common source of infection that sexual contacts serve as a mode of transmission. the principal way of transmission is through blood and blood products., hbv infection is considered to be the 10th leading cause of death (4). regarding the fact that hbv is preventable, such studies may provide a better understanding of the epidemiological pattern of hbv as well as an insight in to the success of vaccination programs in previous years. i, ii, iii and iv represent idealized patterns of commonly observed hbv dna integrants in cellular dna of hbv-related hcc. hbeag, hbeab, and hbcab-igm elisa tests were performed for hbsag-positive samples. (basic local alignment search tool)blast (stand-alone)blast link (blink)conserved domain database (cdd)conserved domain search service (cd search)genome protmaphomologeneprotein clustersall homology resources. (basic local alignment search tool)blast (stand-alone)blast link (blink)conserved domain database (cdd)conserved domain search service (cd search)e-utilitiesprosplignprotein clustersprotein databasereference sequence (refseq)all proteins resources. descriptive statistical tests such as proportion and mean were used to compute the socio-demographic, behavioral and the outcome variable. regional review of hepatitis b and c virus infections among pregnant women in arab and african countries. all patients with rheumatic diseases commencing immunosuppressive therapy should be screened for hepatitis b surface antigen (hbsag); those who are negative for hbsag should be screened for hepatitis b core antibody (hbcab) and hepatitis b surface antibody (hbsab) as well. reports have shown that 68,600 people die of hbv infection and more than 300,000 deaths due to liver cancer secondary to hepatitis b every year globally. prevalence, correlates and pattern of hepatitis b surface antigen in a low resource setting. hbsag rate has been reported for different provinces of iran. a systematic analysis for the global burden of disease study. afterwards, the blood was allowed to clot at room temperature for about 30 minutes as recommended by testing kit’s manufacturer (dialab gmbh, austria). μl of 10xpcr buffer, 20 pmol of forward (5'-cggtaaaaagggactcaagat-3') and reverse (5'-gtggtggacttctctcaattttc-3') primers, 1. discussionthe prevalence of hbsag in middle eastern countries ranges between 2% and 20% (12). our data demonstrated an elevated risk of hbsag infection among older subjects. these include transcriptional activation of cellular growth regulatory genes, modulation of apoptosis and inhibition of nucleotide excision repair of damaged cellular dna.: umare a, seyoum b, gobena t, haile mariyam t (2016) hepatitis b virus infections and associated factors among pregnant women attending antenatal care clinic at deder hospital, eastern ethiopia.
Sero-Prevalence of Hepatitis B Virus Infection among Blood Donorsfactors such as history of abortion, nose piercing, surgical procedure and history of multiple sexual partners were significantly associated with hbv infection. the age of the study participants range between 15 and 40 years with a mean age of 25 years. perinatal and early childhood transmissions are the main routs of hbv infection in high and intermediate endemic areas . similarly, history of surgical procedure was significantly associated with hbv infection (aor 13./support this study was supported by mashhad university of medical sciences, mashhad, iran (grant no. the trend indicated a strong association between age and hbsag infection. meanwhile, after the purpose of the study was explained to the subjects, they were asked to participate voluntarily in the study. although hcc is a malignancy with a poor prognosis, the availability of an effective vaccine against hbv infection, and its inclusion in the expanded programme of immunization of many countries, augurs well for the eventual elimination of hbv-associated hcc. the subject area "surgical and invasive medical procedures" applicable to this article? 2cohesive overlap and surrounding regions of hepatitis b virion dna with commonly observed hbv dna integration patterns. the prevalence of hbv infection is high in the western pacific and south-east asia; however, a variable pattern has been observed in different regions of the middle-east (4). next, samples were collected haphazardly from blocks in every subdivision. serum was withdrawn for each study subject and used to test for hepatitis b surface antigen (hbsag) by an enzyme linked immunosorbent assay (elisa) test kit. sample size was statistically calculated based on single population proportion formula by taking 7. it is also advisable to implement nosocomial infection prevention strategies to prevent the transmissions of hbv through health care related activities such as surgical procedures. Binary logistic regression analysis was used to examine the association between explanatory variables and outcome variable. hbv infection is one of a serious public health problem worldwide and it is 50–100 times more contagious than hiv [2, 3]. recent studies have shown that the prevalence of hbv is remarkably varied in different provinces of iran. thus, to decrease the prevalence of this viral infection, we recommend that health education programs on the mode of hbv transmission, high-risk behaviors and methods of preventions should be instituted at antenatal care clinics to raise the awareness of mothers. & tutorialsncbi education pagencbi handbookncbi help manualncbi newsall training & tutorials resources. anti-hbe and hbe-ag elisa tests (delaware biotech, usa) were carried out to assess the replication of hbv in infected individuals. & medicinebookshelfdatabase of genotypes and phenotypes (dbgap)genetic testing registryinfluenza virusmap vieweronline mendelian inheritance in man (omim)pubmedpubmed central (pmc)pubmed clinical queriesrefseqgeneall genetics & medicine resources. written consent was obtained from each study participant prior to data collection and they participated voluntarily in the study. this finding suggests that the vertical transmission of hbv infection may be a serious public health problem in deder district. but, in this study, positive hiv test result was not observed in all study participants. protocol for assessing prevalence of hepatitis b infection in antenatal patients.-utilitiesjournals in ncbi databasesmesh databasencbi handbookncbi help manualncbi newspubmedpubmed central (pmc)pubmed clinical queriespubmed healthall literature resources.
study was conducted at deder hospital located in deder town, east hararghe zone, oromia regional state, eastern ethiopia that is about 458 km from the capital city of ethiopia, addis ababa. is among the countries with high burden of hiv infection and it is located in a region classified as high endemic area for hbv . it has been noticed that the risk of hbv transmission decreases in a setting where there is a periodic perinatal hbv screening, immunoprophylaxis given to infants born to hbv infected mothers and hepatitis b vaccine administered both to high risk mothers and to all newborn infants . chronic carriers of hbv have an elevated risk of developing cirrhosis and hepatocellular carcinoma (hcc) which leads to death of an estimated 0. tavakkoli h, mir-nasseri mm, poustchi h, afshar p, motalebi mn, mohammadkhani a, et al. having history of nose piercing were more likely to be infected (aor 8. antenatal screening for hbsag to all pregnant women and vaccination of their babies at birth has been recommended widely, yet it is not a routine practice in most health settings of ethiopia . information on socio-demographic and other pertinent data was collected by trained data collectors using a pre-tested standard questionnaire adapted from the who “protocol for assessment of hepatitis b infection in antenatal patients” . study determined that the prevalence of hbv infection among pregnant women was 6. statistical association of predictor variables with hbv infection, among pregnant women attending anc clinic at deder hospital, eastern ethiopia, 2015, (n = 318). one significant limitation of our study was not having enough data on medical history of patients such as previous infection with blood-borne diseases like htlv and hiv, which are prevalent in our region. risk factors for hepatitis b virus infection among pregnant women in lagos, nigeria., it is estimated that 240 million people are chronically infected with hepatitis b . r, khanna p, prinja s, rajput m, chawla s, bairwa m. Hepatitis B virus (HBV) infection is a serious public health problem worldwide. a comprehensive immunization strategy to eliminate transmission of hepatitis b virus infection in the united states: recommendations of the advisory committee on immunization practices (acip) part ii: immunization of adults. global, regional and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013. cite this cite this paper as shakeri mt, foghanian b, nomani h, ghayour-mobarhan m, nabavinia ms, rostami s, et al. results of some hbv pcr tests with specific viral primers are given in figure 2. it seems that the national expanded vaccination program was successful, at least among the younger generation, to control the spread of hepatitis b virus. the samples were transported to the red cross society blood bank laboratory, harar branch, ethiopia in a cold box for serological test. seroprevalence of hbsag and its risk factors among pregnant women in jimma, southwest ethiopia. was estimated that over 5 million people are living with chronic hbv infection among the general population of ethiopia .. materials and methodsbased on multistage cluster-sampling method, 3198 people were recruited from march 2010 to november 2011 for the study of hbv infection in mashhad. the role of anti-hbc igm in screening of blood donors. accordingly we advocate that health education programs on the mode of hbv transmission, high-risk behaviors and methods of preventions should be instituted at antenatal care clinics to raise the awareness of mothers and limit the spread of infection. these few studies indicated that hepatitis b infection among pregnant women raise a public health concern.
according to the sequence of their registration, they were allowed to enter into the anc room for routine follow-up care one by one. seroprevalence of hiv-1, hbv, htlv-1 and treponema pallidum among pregnant women in a rural hospital in southern ethiopia. positive and negative controls were run along with each batch of elisa test kit. a mathematical model to estimate global hepatitis b disease burden and vaccination impact. binary logistic regression analysis was used to examine the association between explanatory variables and outcome variable. seroprevalence of hepatitis b infection during pregnancy and risk of perinatal transmission. other possible causes for these huge statistical results such as confounding effects, multicollinearity and the validity of regression model were addressed at the stage of study design and during data analysis.% of sexually transmitted infections among women attending antenatal care were accounted for hbv infection . similar findings reported in addis ababa, ethiopia ; and in nigeria . the data displayed a statistically significant correlation between gender and hbsag frequency, with the prevalence being higher among males (p = 0. for the purpose of this study, only hbsag was determined which tells about active infection rather than total prevalence. showed that in three provinces of iran, tehran, hormozgan and golestan, the frequency of hbsag was 2. seroprevalence and transmission of hepatitis b virus among delivering women and their new born in selected health facilities, addis ababa, ethiopia: a cross-sectional study. following the registration of 3198 individuals in the study, informed consents, which were approved by the ethic’s committee of mums, were obtained, and a questionnaire was filled for each individual. dow bc, macvarish i, barr a, crawford rj, mitchell r. our data showed the prevalence of hbv is low in our region. the prevalence of hbv infection was seemingly low in mashhad; however, an upward trend was observed in older subjects probably due to successful hbv vaccination coverage in the younger generation. resourceschemicals & bioassaysbiosystemspubchem bioassaypubchem compoundpubchem structure searchpubchem substanceall chemicals & bioassays resources. sero-prevalence and risk factors of hepatitis b virus and human immunodeficiency virus infection among pregnant women in bahir dar city, northwest ethiopia. due to the vaccination program, prevalence of hbv, particularly among the younger generation, is reported to have declined in recent years in iran.% prevalence of hbv infection from previous study , desired precision of 3%, a 95% confidence level and 10% non- response rate. this high incidence of infection could be attributed to poor practices of infection prevention control during abortion and related activities. last but not least, we are grateful to all our study participants and also to sciencedit-dw for editing our manuscript. we neither tested for anti-hbc (igm), nor followed up women to determine if they had a chronic or an acute infection. this study aims to determine the prevalence of hbv infection and associated factors among pregnant women. & rnablast (basic local alignment search tool)blast (stand-alone)e-utilitiesgenbankgenbank: bankitgenbank: sequingenbank: tbl2asngenome workbenchinfluenza virusnucleotide databasepopsetprimer-blastprosplignreference sequence (refseq)refseqgenesequence read archive (sra)spligntrace archiveunigeneall dna & rna resources. variations in hbv genome sequences may be important in hepatocarcinogenesis, although their significance has not yet been completely elucidated.